Neutralizing Complement C5a Protects Mice with
Pneumococcal Pulmonary Sepsis

Müller-Redetzky H, Kellermann U, Wienhold SM, Gutbier B, Lienau J, Hellwig K, Reppe K, Letsiou E, Tschernig T, Scholz M, Ahnert P, Maasch C, Hoehlig K, Klussmann S, Vater A, Firsching TC, Hoppe J, Suttorp N, Witzenrath M. Anesthesiology. 2020 Apr;132(4):795-807. doi: 10.1097/ALN.0000000000003149. PMID: 32101978 Free article;

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Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects

Ajona D, Zandueta C, Corrales L, Moreno H, Pajares MJ, Ortiz-Espinosa S, Martínez-Terroba E, Perurena N, de Miguel FJ, Jantus-Lewintre E, Camps C, Vicent S, Agorreta J, Montuenga LM, Pio R, Lecanda F. Am J Respir Crit Care Med. 2018 May 1;197(9):1164-1176. doi: 10.1164/rccm.201703-0660OC.

C5a Blockade Increases Regulatory T Cell Numbers and Protects Against Microvascular Loss and Epithelial Damage in Mouse Airway Allografts

Khan MA, Alanazi F, Ahmed HA, Vater A, Assiri AM, Broering DC. Front Immunol. 2018 May 24;9:1010. doi: 10.3389/fimmu.2018.01010. eCollection 2018. PMID: 29881374 Free PMC article.

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

Ajona D, Ortiz-Espinosa S, Moreno H, Lozano T, Pajares MJ, Agorreta J, Bértolo C, Lasarte JJ, Vicent S, Hoehlig K, Vater A, Lecanda F, Montuenga LM, Pio R. Cancer Discov. 2017 Jul;7(7):694-703. doi: 10.1158/2159-8290.CD-16-1184. Epub 2017 Mar 13.

Low-Intensity Training and the C5a Complement Antagonist NOX-D21 Rescue the mdx Phenotype through Modulation of Inflammation

Hyzewicz J, Tanihata J, Kuraoka M, Nitahara-Kasahara Y, Beylier T, Ruegg UT, Vater A, Takeda S. Am J Pathol. 2017 May;187(5):1147-1161. doi: 10.1016/j.ajpath.2016.12.019. Epub 2017 Mar 18. PMID: 28315675

Intravitreal inhibition of complement C5a reduces choroidal neovascularization in mice

Brockmann C, Brockmann T, Dege S, Busch C, Kociok N, Vater A, Klussmann S, Strauß O, Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2015 Oct;253(10):1695-704. doi: 10.1007/s00417-015-3041-z. Epub 2015 May 16. PMID: 25981118

Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy

Mavroidis M, Davos CH, Psarras S, Varela A, C Athanasiadis N, Katsimpoulas M, Kostavasili I, Maasch C, Vater A, van Tintelen JP, Capetanaki Y. Basic Res Cardiol. 2015 May;110(3):27. doi: 10.1007/s00395-015-0485-6. Epub 2015 Apr 8. PMID: 25851234

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

Yatime L, Maasch C, Hoehlig K, Klussmann S, Andersen GR, Vater A. Nat Commun. 2015 Apr 22;6:6481. doi: 10.1038/ncomms7481. PMID: 25901944 Free PMC article.

A novel C5a-neutralizing mirror-image (L-)aptamer prevents organ failure and improves survival in experimental sepsis

Hoehlig K, Maasch C, Shushakova N, Buchner K, Huber-Lang M, Purschke WG, Vater A, Klussmann S. Mol Ther. 2013 Dec;21(12):2236-46. doi: 10.1038/mt.2013.178. Epub 2013 Jul 26. PMID: 23887360 Free PMC article

Targeting complement component 5a promotes vascular integrity and limits airway remodeling

Khan MA, Maasch C, Vater A, Klussmann S, Morser J, Leung LL, Atkinson C, Tomlinson S, Heeger PS, Nicolls MR. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6061-6. doi: 10.1073/pnas.1217991110. Epub 2013 Mar 25. PMID: 23530212 Free PMC article.